For research use only · Not for human use
IGF-1 LR3
Long-acting IGF-1 analog for cell and muscle research
In short
IGF-1 LR3 is a modified version of the body's insulin-like growth factor-1 (IGF-1), engineered to stay active longer. It is also widely used in cell-culture work.
Evidence level: Mostly preclinicalData comes from cell and animal studies; there are no human studies.
Size
- Independently tested. Janoshik Analytical results published.
- QR verification. An authenticity code on every box.
Chemistry
| CAS# | Formula | Molar mass |
|---|---|---|
| 946870-92-4 | C400H625N111O115S9 | 9117.6 g/mol |
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Request certificateWhat is IGF-1 LR3?
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analog of human IGF-1. The 'Long' refers to a 13-amino-acid extension at the N-terminus, and 'R3' indicates an arginine substitution at position 3, a modification that reduces affinity for IGF-binding proteins in preclinical research models. Supplied in lyophilized form.
IGF-1 LR3 emerged from research efforts in the late 1980s and early 1990s to create modified versions of insulin-like growth factor with altered binding profiles. Scientists at GroPep in Adelaide, Australia, were among the first to develop this modified peptide, characterizing it in the context of native IGF-1's rapid sequestration by circulating binding proteins.
The key structural change was twofold: adding 13 extra amino acids to the N-terminus of the peptide sequence and substituting arginine for glutamic acid at position 3. These modifications reduced affinity for IGF-binding proteins (IGFBPs) in preclinical assays, yielding a research-grade analog with a longer apparent half-life in in-vitro and animal models than native IGF-1.
Since its development, IGF-1 LR3 has appeared in peer-reviewed preclinical publications examining IGF-1 receptor signaling in cell culture and animal models. Its reduced IGFBP affinity makes it a common tool compound for investigating IGF-1R-mediated pathways in research settings. This product is intended for research use only.
How should IGF-1 LR3 be stored?
Research peptides are supplied lyophilized (freeze-dried) . Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution .
Related research compounds
References
- Francis GL, et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. Journal of Molecular Endocrinology. 1992;8(3):213-223. PMID 1378742
- Tomas FM, et al. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochemical Journal. 1992;282(Pt 1):91-97. PMID 1371669
- Ballard FJ, et al. Does IGF-I ever act through the insulin receptor? Cytokine & Growth Factor Reviews. 2007;18(1-2):7-12.
IGF-1 LR3 is available for laboratory research purposes only.