For research use only · Not for human use
Semax
Cognitive and nervous-system research
In short
Semax is a synthetic 7-amino-acid peptide derived from a fragment of the ACTH hormone. It was developed in Russia and is studied in brain and nervous-system research.
Evidence level: Approved drug ingredientLicensed as a drug in Russia; not approved in the U.S. or EU. International clinical data is limited.
Size
- Independently tested. Janoshik Analytical results published.
- QR verification. An authenticity code on every box.
Chemistry
| CAS# | Formula | Molar mass |
|---|---|---|
| 80714-61-0 | C37H51N9O10S | 813.9 g/mol |
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Request certificateWhat is Semax?
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone fragment ACTH(4-10) with a C-terminal Pro-Gly-Pro extension. Published preclinical investigations have examined its interactions with BDNF and NGF gene expression, melanocortin receptor binding, and monoaminergic signaling in rodent and in vitro models.
Semax was developed in the 1980s at the Institute of Molecular Genetics of the Russian Academy of Sciences by a team led by Nikolai Myasoedov and Isaak Ashmarin. The researchers were investigating fragments of adrenocorticotropic hormone (ACTH) that retained neurotropic activity without the hormonal effects on the adrenal glands.
The ACTH(4-10) fragment studied by the group was rapidly degraded in preclinical models. By adding a Pro-Gly-Pro tripeptide to the C-terminus—the same modification later used in Selank—they produced a heptapeptide with improved stability characteristics in published assays.
Semax has been the subject of extensive preclinical investigation in Russia since the early 1990s. Published research has examined its interactions with BDNF and NGF signaling, melanocortin receptors, and monoaminergic pathways. This product is intended for research use only.
How should Semax be stored?
Research peptides are supplied lyophilized (freeze-dried) . Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution .
Related research compounds
References
- Ashmarin IP, et al. The nootropic drug Semax: a review of its mechanisms of action. Neuroscience and Behavioral Physiology. 2005.
- Dolotov OV, et al. Semax regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006. PMID 16996037
- Gusev EI, et al. Semax in prevention of disease progress in patients with cerebrovascular insufficiency. Zhurnal Nevrologii i Psikhiatrii. 2005.
- Agapova TY, et al. Effects of Semax on dopamine and serotonin metabolism in rat brain. Doklady Biological Sciences. 2007.
Semax is available for laboratory research purposes only.