For research use only · Not for human use
MOTS-C
The metabolism peptide encoded by mitochondria
In short
MOTS-C is a 16-amino-acid peptide encoded in mitochondrial rather than nuclear DNA. It is studied in energy and glucose metabolism and in exercise biology.
Evidence level: Mostly preclinicalMost publications are animal and cell studies.
Size
- Independently tested. Janoshik Analytical results published.
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Chemistry
| CAS# | Formula | Molar mass |
|---|---|---|
| 1627580-64-6 | C101H152N28O22S2 | 2174.6 g/mol |
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Request certificateWhat is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a 16-amino-acid mitochondrial-derived peptide (MDP). It has been examined in preclinical models of AMPK signaling and mitochondria-to-nucleus retrograde communication.
MOTS-C was first described in 2015 by Dr. Pinchas Cohen and his research team at the University of Southern California's Leonard Davis School of Gerontology. The characterization identified a short open reading frame within the mitochondrial 12S rRNA gene encoding a distinct peptide, adding to an emerging class of mitochondrial-derived peptides.
The peptide's name reflects its origin: MOTS-C stands for Mitochondrial Open Reading Frame of the 12S rRNA type-C. It is a 16-amino-acid sequence encoded within a region of mitochondrial DNA previously considered non-coding. Its characterization contributed to an ongoing research field focused on mitochondrial-derived peptides (MDPs) and mitochondria-to-nucleus signaling.
How should MOTS-C be stored?
Research peptides are supplied lyophilized (freeze-dried) . Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution .
Related research compounds
References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-454. PMID 25738459
- Kim KH, et al. MOTS-c: A mitochondrial-encoded regulator of the nucleus during metabolic stress. Journal of the American Society of Nephrology. 2018;29(10):2367-2369. PMID 29983246
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021;12(1):470. PMID 33473109
MOTS-C is available for laboratory research purposes only.