For research use only · Not for human use
R-3
Next-generation triple agonist for weight and metabolism research
In short
R-3 is a synthetic peptide that targets three hormone receptors at once: GLP-1, GIP and glucagon. It belongs to the same family as semaglutide and tirzepatide; the difference is that it also targets the glucagon receptor.
Evidence level: Human clinical trialsPhase 2 results were published in NEJM in 2023; Phase 3 trials are ongoing. Not yet an approved drug.
Size
- Independently tested. Janoshik Analytical results published.
- QR verification. An authenticity code on every box.
Chemistry
| CAS# | Formula | Molar mass |
|---|---|---|
| 2381089-83-2 | C221H342N46O68 | 4731.3 g/mol |
INDEPENDENT LAB ANALYSIS
R-3 10mg
Every result on this certificate
- R-310.99 mgReported
- Purity95.462%Reported
- Tests requested
- Common GLP-1 peptide blind test (Semaglutide, Tirzepatide and R-3)
- Ordered / Received / Analyzed
- 16 Jul 2026 / 24 Jul 2026 / 30 Jul 2026
- Lab comment
- Purity assessment includes peptide peaks only.
Verify authenticity · Access code
PDGXMFSTL1E8
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What is R-3?
R-3 is a synthetic peptide characterized in published research as a triple agonist at the GLP-1, GIP, and glucagon receptors. It has been examined in preclinical models of incretin and glucagon receptor signaling.
R-3 is a synthetic peptide characterized in published research as an agonist at the GLP-1, GIP, and glucagon (GCGR) receptors, with engineered potency ratios across the three targets. It is used as a laboratory tool for investigating incretin and glucagon receptor signaling in cellular and in vitro model systems.
Its triple-receptor profile has been examined in preclinical research as a reference compound for probing receptor crosstalk and downstream signaling cascades that are not accessible with single- or dual-receptor ligands.
R-3 has been referenced in peer-reviewed publications examining incretin receptor pharmacology. This product is intended for research use only.
How should R-3 be stored?
Research peptides are supplied lyophilized (freeze-dried) . Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution .
Related research compounds
References
- Coskun T, et al. Cell Metabolism. 2022;34(9):1234-1247. PMID 35985340
- Jastreboff AM, et al. New England Journal of Medicine. 2023;389(6):514-526. PMID 37366315
- Rosenstock J, et al. The Lancet. 2023;402(10401):529-544. PMID 37385280
- Loomba R, et al. Nature Medicine. 2024;30(7):2024-2033. PMID 38858523
R-3 is available for laboratory research purposes only.