For research use only · Not for human use
PT-141
Melanocortin system and sexual-function research
In short
PT-141 (bremelanotide) is a synthetic peptide that targets melanocortin receptors in the brain. It is used to study the central nervous-system side of sexual desire and function.
Evidence level: Approved drug ingredientThe active ingredient (bremelanotide) is FDA-approved in the U.S. for a specific indication. This product is a research material, not a drug.
Size
- Independently tested. Janoshik Analytical results published.
- QR verification. An authenticity code on every box.
Chemistry
| CAS# | Formula | Molar mass |
|---|---|---|
| 189691-06-3 | C50H68N14O10 | 1025.2 g/mol |
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Request certificateWhat is PT-141?
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from alpha-melanocyte-stimulating hormone. In preclinical research, it has been examined as an agonist of melanocortin receptors, with a focus on MC4R binding and downstream intracellular signaling in neuronal cell models.
PT-141, also called Bremelanotide, originated from Melanotan 2 research at the University of Arizona. Scientists there were characterizing melanocortin receptor analogs and observed MC4R-mediated signaling activity distinct from the melanogenesis pathways that were the original focus of investigation.
Researchers subsequently modified the Melanotan 2 structure to produce a cyclic heptapeptide with altered receptor selectivity. The resulting compound, PT-141, has since appeared in peer-reviewed preclinical publications examining melanocortin receptor binding and central nervous system signaling.
In preclinical models, Bremelanotide has been examined for its melanocortin receptor pharmacology. The research-grade form is used in melanocortin receptor signaling studies. This product is intended for research use only and is not for human consumption.
How should PT-141 be stored?
Research peptides are supplied lyophilized (freeze-dried) . Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution .
Related research compounds
References
- Pfaus JG, et al. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proceedings of the National Academy of Sciences. 2004.
PT-141 is available for laboratory research purposes only.