For research use only · Not for human use
Selank
Tuftsin analog for stress and anxiety research
In short
Selank is a synthetic 7-amino-acid peptide derived from the immune peptide tuftsin. It was developed in Russia and is studied in stress, anxiety and cognition research.
Evidence level: Approved drug ingredientLicensed as a drug in Russia; not approved in the U.S. or EU. International clinical data is limited.
Size
- Independently tested. Janoshik Analytical results published.
- QR verification. An authenticity code on every box.
Chemistry
| CAS# | Formula | Molar mass |
|---|---|---|
| 129954-34-3 | C33H57N11O9 | 751.9 g/mol |
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Request certificateWhat is Selank?
A synthetic heptapeptide derived from the immunomodulatory tetrapeptide tuftsin by addition of a C-terminal Pro-Gly-Pro sequence. Selank has been examined in preclinical models of GABAergic signaling, monoamine metabolism, and tuftsin-related immunomodulatory pathways.
Selank was developed in the late 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences, under the direction of Nikolai Myasoedov. The research team was exploring derivatives of tuftsin, an immunomodulatory tetrapeptide naturally present in the body as part of the immunoglobulin G heavy chain.
The scientists added a Pro-Gly-Pro sequence to tuftsin, producing a heptapeptide with greater metabolic stability. In preclinical characterization work, the modified molecule retained tuftsin-associated immunomodulatory activity and was also observed to influence central-nervous-system endpoints in rodent assays.
Selank has been the subject of extensive preclinical investigation since its development, with published research examining GABAergic signaling, monoamine metabolism, immunomodulatory activity, and neurotrophic-factor expression. This product is intended for research use only.
How should Selank be stored?
Research peptides are supplied lyophilized (freeze-dried) . Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution .
Related research compounds
References
- Seredenin SB, et al. Anxiolytic action of the synthetic peptide Selank. Bulletin of Experimental Biology and Medicine. 1998.
- Kozlovskii II, et al. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neuroscience and Behavioral Physiology. 2003. PMID 14969422
- Zozulia AA, et al. Effects of Selank on the immunity status in patients with generalized anxiety disorder. Zhurnal Nevrologii i Psikhiatrii. 2008.
Selank is available for laboratory research purposes only.